By T. Umbrak. Wilson College.
Experimental animal studies of lamotrigene during embryogenesis are equivocal discount 100 mg gyne-lotrimin with visa, with a report of no increased frequency of congenital anomalies generic 100 mg gyne-lotrimin otc, and another reporting an increased frequency of birth defects generic 100 mg gyne-lotrimin overnight delivery. Levetiracetam No epidemiological studies of infants born after exposure to levetiracetam during the first or subsequent trimester of gestation have been published. Nonetheless, the nature of the disease being treated (seizure disorder) and the drug (anticonvulsive agent) raise concerns that infants exposed to levetirecetam during gestation may be at an increased risk of birth defects. Gabapentin Congenital anomalies have been reported among 44 women who used gabapentin dur- ing pregnancy (Montouris, 2003), but (1) the anomalies (hypospadias, renal agenesis) are not consistent with the fetal anticonvulsant syndrome and (2) it is not clear from the published report precisely when during pregnancy the women were exposed. A case report of an infant with holoprosencephaly and cyclopia whose mother took carba- mazepine and gabapentin during pregnancy has been published (Rosa, 1995), but it is unclear what, if any, association this has with prenatal drug exposure. Other isolated case reports have also been published (Bruni, 1998; Morrell, 1996), but their relation- ship to risks associated with gabapentin use during pregnancy is unknown. A case report described a child whose features resembled the ‘fetal anticonvulsant syndrome’ and whose mother took gabapentin and valproic acid during pregnancy (Moore et al. Experimental animal studies with mice, rats, and rabbits have not found an increased frequency of congenital anomalies among offspring exposed to gabapentin during embryogenesis. Oxcarbazepine Important note: oxcarbazepine is an anticonvulsant drug closely related to a known human teratogen, carbamazepine. This drug has been part of a polytherapy regimen in most published reports of its use during pregnancy, confounding its possible causal role. Among 248 pregnancies exposed to oxcarbazepine monotherapy during pregnancy, there were six congenital anomalies (2. Among 61 infants whose mothers were given polytherapy that included oxcarbazepine, four birth defects (6. Among 35 infants born to epileptic women treated with oxcarbazepine monotherapy in one series, no congenital anomalies were found (Meischenguiser et al. Among 20 infants born to women who took polytherapy anticonvulsant regimen that included 176 Anticonvulsant drugs during pregnancy oxcarbazepine, one baby was born with a major cardiac congenital anomaly. One of nine infants born to epileptic women treated in the first trimester with oxcarbazepine monotherapy had multiple major birth defects involving the genitourinary tract (Kaaja et al. Isolated case reports involving polytherapy (including oxcarbazepine) of single infants with spina bifida, short spine, hypospadias, or limb reduction defects have been published (Lindhout et al. Tiagabine Among nine infants whose mothers took tiagabine during pregnancy, one infant had a congenital anomaly, but this was not similar to any of the anomalies in the ‘fetal anti- convulsant syndrome’ (Morrell, 1996). In unpublished experimental animal studies (rats, rabbits) employing doses much higher than the human dose, and at doses toxic to the mother, there were increased fre- quencies of congenital anomalies in rats but not rabbits. None of this information is rel- evant to the assessment of human risk of birth defects following exposure to tiagabine during embryogenesis. Topiramate In a case series three normal infants were reported whose mothers were treated with top- iramate sometime during gestation (Morrell, 1996). In another case report, a pattern of minor anomalies similar to the ‘fetal anticonvulsant syndrome’ were observed in an infant whose mother took topiramate monotherapy throughout pregnancy (Hoyme et al. The relevance of these anecdotal reports, if any, to human risks following exposure to topiramate during embryogenesis is unknown. The results of studies of rats, mice, and rabbits exposed to topiramate during embryo- genesis are conflicting. Rats had limb defects at the highest doses, mice had craniofacial defects, and rabbits had vertebral anomalies. The inconsistent findings and the lack of peer review of these unpublished studies confound any possible interpretation of these data. Vigabatrin Among 47 infants born to women who took vigabatrin during the first trimester two (4. In several studies, major anomalies were increased among mice exposed to vigabatrin during embryogenesis, and cleft palate occurred among rabbits exposed to maternally and fetotoxic doses. No increased frequency of congenital anomalies was found among rats exposed to vigabatrin during embryogenesis. Zonisamide Zonisamide is an anticonvulsant used either in monotherapy or polytherapy to treat a broad spectrum of epileptic conditions (Oguni et al. In one Special considerations 177 small prospective case series of 26 infants born to women treated throughout pregnancy with zonisamide as part of a polytherapy anticonvulsant regimen, two infants (7. A child whose mother took zonisamide, carbamazepine, pheny- toin, sodium valproate, and a barbiturate during pregnancy was reported with features of anticonvulsant embryopathy (Noda et al. Increased frequencies of congenital anomalies were found in animal studies of terato- genicity of zonisamide in rats (cardiac), mice (visceral, skeletal), dogs (cardiac), and monkeys (pregnancy wastage) (Terada et al. If a pregnant woman presents on anticonvulsant therapy, she should be given counseling regarding the two- to three-fold increased risk of malformations. She should also be offered high-resolution ultrasound and alpha-fetoprotein screening at appropriate gestational intervals. It should be emphasized that these techniques, although helpful, may not rule out anticonvulsant embryopathy. It may be possible to discontinue medications in certain patients who have been seizure-free for protracted periods of time, especially in patients who have had petit mal seizures. Trimethadione and paramethadione are generally contraindicated during pregnancy, and valproic acid should be avoided if possible. One of the succinimides, etho- suximide, would appear to be a better choice for petit mal seizures in the rare pregnant patient where it is indicated. Monitoring of serum levels of anticonvulsants may be indicated in some pregnant women, especially those with increased seizure activity. A suggested man- agement protocol for pregnant patients with epilepsy is summarized in Box 9. Patients should be counseled that anticonvulsant therapy during pregnancy is associ- ated with risks of serious birth defects. For example, with valproic acid and carba- mazepine, the risk for neural tube defects, spina bifida in particular, is increased with exposure during the first trimester (Table 9. Risks for other congenital anomalies are increased when associated with exposure to other anticonvulsants during embryogene- sis (Table 9.
However discount gyne-lotrimin 100 mg online, part of that rebuilding process involves When a muscle is overworked (contracted “too much”) buy generic gyne-lotrimin 100 mg line, it producing fibrin or “scar tissue generic gyne-lotrimin 100 mg free shipping,” which forms a sort of may simply radiate pain, but oftentimes a knot also will latticework on which the body can build new tissue. Knots are tender, feel hard to the touch, and can require body, the more inflexible you become. If you think of the muscle as a Typically, once the repair work is finished, a special type of length of hair—since muscles are made of up fibers similar to enzymes called proteolytic enzymes come in to complete the hair strands—a normal muscle would look like healthy, job by breaking down the fibrin and whisking it away. First, the waste products produced by your muscle cells aren’t removed quickly, so they settle into the fibers. Second, the cells in those areas aren’t getting as much oxygen as they’re used to getting—so they’re mildly oxygen deprived. Third, your blood transports the fuel that powers the “unlocking” mechanism within those last few muscle fibers that are “stuck” together. This creates a vicious self- reinforcing cycle where a knot causes slow blood circulation, which prevents the knot from releasing itself, which causes the knot to persist even further. The result is a trigger point, or what most people think of as a knot, in their muscle. It’s also important to note that trigger points can develop in tendons, and because tendons are so much less vascular, meaning they get so much less blood flow, they often are much harder to treat effectively. This knot slows blood flow through the muscle, causing A physical dysfunction occurs when your body posture several problems. First, the waste products produced by your and/or mechanics are no longer optimal, or “normal,” and are muscle cells aren’t removed quickly, so they settle into the now creating excessive wear and tear on your muscles, fibers. This can show up simply as Second, the cells in those areas aren’t getting as much pain, or it can develop into a medical condition, such as oxygen as they’re used to getting—so they’re mildly oxygen scoliosis, a joint condition, disc herniation, and more. If you pull one string up tight and leave Third, your blood transports the fuel that powers the the others loose, the body will change posture. The same is “unlocking” mechanism within those last few muscle fibers true of your muscles. Without ample blood circulation, body out of its normal position and the result will be a curved these muscle fibers never unlock. Vertebrae are pulled to the right or These three conditions combine to cause inflammation, left, straining the spine. For example, if you sit for many hours of the day (like many people do), your hip flexors—those muscles on the front of To learn more about trigger points, be sure to watch the your hips that pull your knees up—become short and tight. You can find them at: This tightness can “pull” the top of the pelvis on one or both sides downward, which creates excessive curvature in your www. Then you have constant strain placed on the muscles of the lower back, but that’s nothing compared to the 39 The 7-Day Back Pain Cure uneven compression placed on your discs as a result of the excess curvature. This is just one example of how physical dysfunctions develop and wreak havoc on our bodies. As someone with back, neck, or sciatic pain, it is critical that you understand this process, as it holds the key to you getting lasting relief and also knowing how to prevent or better deal with future flare-ups. How Physical Dysfunctions Create “Conditions” and Pain If you regularly carry a wallet, cell phone, or other object in your pants pocket, try the following exercise. Put on a pair of fairly snug-fitting jeans that have a back pocket and sit in a chair. Then stand up, put the wallet or cell phone in the back pocket and sit back down again. The hip on the same side as the wallet or phone will rise up a little bit, and your shoulders and neck will adapt to compensate. This is the same thing your body does when lifting a heavy bag, though the effect is a bit subtler. Here’s another demonstration you should do in front of a full-length mirror or with a friend who can take a photograph of you. If you were to put a carpenter’s bubble level on the area covered by your index finger and thumb, would you be “level”? But if your index finger and thumb lean toward the front of your body, your hips lean too far forward. Similarly, if your finger and index finger lean toward the back of your body, your hips lean too far backward, which also can lead to back pain. Look at This is just one example of how physical dysfunctions yourself in the mirror or in the photos. As someone with on the side of your leg or do they rest more toward the front, back, neck, or sciatic pain, it is critical that you understand on the big leg muscles called the quadriceps? Put on a pair tighter (not always, but typically stronger) than the of fairly snug-fitting jeans that have a back pocket and sit in a corresponding muscles in the back. Then stand up, put the time driving and have to reach for the steering wheel, or who wallet or cell phone in the back pocket and sit back down sit in front of a computer where the keyboard is too far away, again. The Slippery Slope Toward Back Pain This is the same thing your body does when lifting a heavy bag, though the effect is a bit subtler. When a physical condition isn’t corrected, the body starts Here’s another demonstration you should do in front of a to break down. Usually the result is pain, which can exist on full-length mirror or with a friend who can take a photograph its own without signaling any particular condition. Next, conditions also arise as a result of the same lengthy wear and place your hands on your hips. Tight muscles can pull the vertebrae out of alignment, If you were to put a carpenter’s bubble level on the area pinching a nerve or creating a herniated disc. Physical covered by your index finger and thumb, would you be dysfunctions can pressure joints and, over time, stress them to “level”? But if your index finger and the maximum until they develop inflammation and injury. Similarly, if your finger and index finger lean toward the back The pain from these conditions is often triggered by some of your body, your hips lean too far backward, which also can sort of activity, such as heavy lifting, gardening, cleaning, or lead to back pain. Suddenly there is pain, triggered by a muscle spasm, strain, or pull, or by a pinched nerve or inflamed joint.
In syphilis generic 100mg gyne-lotrimin, scrofula 100mg gyne-lotrimin with amex, and in all glandular derangements with general depravity of the system discount 100 mg gyne-lotrimin with visa, marked blood dyscrasia and general impairment of the nutritive functions, this agent is indicated. Its influences are demanded in these cases more especially if there be tumidity and enlargement or distention of the abdominal structures with general atonicity, or in some cases in which there are persistently coated tongue and fetid breath. This is often the condition in which a patient is found following a protracted attack of intermittent fever— ague, and since the entire glandular system has become sluggish from the disease the tonic effects of this agent are here indicated. Its influence can be greatly heightened by the direct nerve tonics and calisaya in such cases as these. Therapy—When blood dyscrasia is present, sluggishness of the digestive apparatus, deficient glandular secretion, impaired secretion of the mucous membranes of the stomach and intestinal canal, this agent is indicated, as, in these cases, its tonic properties are plainly manifested. It is of value in imperfect restoration of these functions after protracted disease, on which it operates with the tonic and restorative stimulants to an excellent advantage. Amenorrhea, leucorrhea and dysmenorrhea, with relaxed condition of the uterine supports and prolapsus, sometimes occurring from the extreme debility following severe fevers, and common, also, with scrofula and other blood dyscrasias, are all materially benefited by corydalis formosa. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 171 In chronic skin disorders with marked cachexia, this agent is speedily curative. It will be found superior to other agents in overcoming eczema with great relaxation of tissue and general plethora. In syphilitic nodules of the bones, in syphilitic and scrofulous ulcerations, its influence is direct, immediate and permanent. If there is persistent ulceration with general breaking down of soft tissue, a strong infusion has been applied externally with good results. This is in part due to its stimulating influence upon the emunctories of the skin, facilitating elimination through the glands of this structure. It has a marked influence, also, upon the kidney function which, while beneficial in its direct influence upon general elimination, is hardly sufficient to enable it to be depended upon as curative of kidney or bladder troubles to the exclusion of the use of more direct agents. Prescribed, from five minims to one and one-half drams, in four ounces of water, a teaspoonful every hour or two. Physiological Action—Digitalis in full doses produces a great rise in arterial pressure, followed by a marked fall. It acts on the inhibitory nerves and on the heart muscle; the increased action being due to vasomotor spasm and to stimulation of the heart itself. A poisonous dose causes depression and a dicrotic pulse, while the immediate effect of moderate doses is to stimulate the heart. Its prolonged use weakens the Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 172 heart muscle by decreasing its normal nutrition. When given in frequent small doses, where absorption is immediate, it influences all of the organic functions as a depressant; it produces irritation of the stomach and bowels, increased action of the kidneys, and a marked change in the character, regularity and frequency of the pulse beat. The influence upon the heart is not always uniform in all such cases, but variable and often unreliable. The influence is marked and more immediate if a large dose is given and repeated a few times. The gastric and intestinal irritation is greatly increased, there is purging, violent vomiting, great prostration with dicrotic or tumultous, irregular, erratic and uncertain heart action. In its general irritating influence upon organic function it may cause so marked an impression upon the renal circulation as to result in spasm of the vessel walls and suspension of renal action-suppression of urine with profound albuminuria. In prostration or profound weakness, in sudden failure from violent injury, from surgical shock or from acute poisoning, or in the crisis of extreme exhausting or protracted disease, its influence given in conjunction with general stimulants is decisive and satisfactory. The agent sustains the action of the heart, but does not impart tone as cactus does, by increased nerve force and improved nutrition of the organ. Its sustaining power can be maintained by proper administration until other measures supply deficient power, by encouraging reaction, or by general improved nutrition. The influence of digitalis in its stimulant effect is nearly diametrically opposed to that of aconite. For this reason digitalis, within the limits of its stimulant action, is a physiological antidote to aconite. It is a sedative in fevers under those circumstances in which aconite is contra- indicated. In prolonged cases where asthenic conditions prevail, and where the temperature remains high, with rapid, feeble, easily compressed pulse or irregular heart action, all the evidences of failure of vital force, digitalis is the fever remedy. It controls the pulse, reduces the Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 173 temperature somewhat, and im. Aconite, veratrum and the synthetic antipyretics will all increase the condition under such circumstances and are contraindicated. In pneumonia, when the disease processes have had full sway, and the heart is unable to properly fill the pulmonary capillaries, and is depressed by the influence of the general disorder, and the general effects of the accumulated carbonic acid within the blood, and is labored and overtaxed and apparently slowly failing, this agent is directly useful. It promptly strengthens the heart and the nervous structure of the pulmonary apparatus at the same time. In minute doses in children, if it be given with belladonna or other heart stimulants, it shows a most desirable influence in this class of cases, but should be stopped as soon as these results are obtained, that no untoward symptoms may occur. Digitalis is a remedy for passive congestion where the blood stasis has occurred from feebleness and failure of the circulatory organs. It exercises a stimulating influence upon the entire apparatus; through its power of increasing heart action it imparts renewed force and an improved capillary tonus in every part. It such cases its influence resembles that of belladonna, although not so marked nor permanent. In valvular diseases of the heart, with muscular relaxation and feebleness, it is a good remedy, but not always the best. It sustains the power for a time in those cases where there is stenosis, and where compensatory dilatation has previously occurred. In feeble, irregular and intermittent heart it is frequently prescribed with excellent results. Like cactus, it is not a remedy for violent heart action from over action of the nervous system, or from sthenic conditions. Cactus is valuable, indeed, in irritable heart from indigestion; in palpitation and irregular action from gastric irritation, while in this case digitalis exercises no beneficial influences whatever. Digitalis is not found in the urine and does not directly influence the secretory or the excretory functions of the kidneys. Renal congestion is overcome because the increased heart impulse drives the blood through the renal capillaries with renewed vigor, and there is thus a copious flow of the urine from improved renal circulation. In cardiac dropsy it acts most promptly if given in infusion in small and frequently repeated doses. In dropsy from post-scarlatinal nephritis, a dram or two of the leaves in a pint of water is thoroughly steeped.