Y. Darmok. Nebraska Wesleyan University.

Alprostadil acts locally purchase 1.5 mg haldol with amex, promoting smooth muscle relaxation buy discount haldol, which causes an increase in blood flow to the corpus cavernosum and produces an erection cheap haldol online american express. Contraindications: Chronic nephritis (until controlled), hyper- sensitivity to beef/pork proteins, hypersensitivity to vasopressin, coronary artery disease, angina pectoris. Contraindicatons Disseminated intravascular coagulaton; hypersensitvity to any component of the product. Onset of Action Duration <1 h 12–14 h Food: Avoid excessive intake of food and drink. View Online 102 Chapter 4 overall pharmaceutical market (excluding generics), as outlined in Figure 4. Sampling Procedures Samples may be categorized broadly into four heads, namely : (a) Gross Sample : A sample that represents the whole lot and may vary from a few grams or less to several pounds based on the nature of the bulk material. A subsequent Government document, Putting full recovery first, provides more detail of the Government’s aim of establishing a treatment system approach that puts more emphasis on people in drug treatment achieving recovery, rather than aiming to simply engage and retain them in treatment. The characterization of each batch with a reference number of “male” or “female” biological units was the frst and mandatory step in the defnition of the pharmacological dosages to be employed by doctors. Of course, disulfde bond formation between thiol groups of cysteine residues is widely used in nature and in peptide design. The sole disadvantage of this method is the need to do the final reaction with ammonia or methylamine inside a sealed pipe. Considerable advances in controlling drug release from delivery systems have been made; such systems are described in detail in Chapters 3, 4 and 16. Chem ical stability Lutrol F 127 (= Pluronic® F 127) stabilizes indom ethacin against hydro- lisis as shown in the following publication sum m ary: Hydrolysis of Indom ethacin in Pluronic F 127 Gels Tom ida H. Permeation of the single-chain neurotoxic botulinum polypeptide depends on cleavage by proteases to a heavy and light chain. In other words, concessions for secret remedies were increasingly granted on the basis of pharmaceutical analysis and clinical trials. Seven cases of non-melanoma skin cancer were observed among patients receiving hydroxyurea maintenance and two cases in the surveyed group. These effects are clearly dose-dependent, as premature infants given 30 mg of menadiol sodium phosphate had higher serum bilirubin concentrations, more Heinz bodies, lower haemoglobin concentrations and lower erythrocyte counts than those given 1 mg. The ramifications of altered protein binding on drug clearance are discussed in Lesson 9. Etoposide-containing regimens have been associated with the development, after a short latency, of leukaemia which is characterized by chromosomal translocations. Incorporation by reference was established by statute and allows Federal agencies to meet the requirement to publish regu- lations in the Federal Register by referring to materials already published else- where. To increase the probability cocrystals, particle-size reduction, and amorphous of success, we [Hovione] recommend that at early-development stages to test other solid dispersions, help to optimize delivery of a drug. Import license will only be given against an existing valid export order and to the extent raw material is required as per that order. Higher polymer concentration may decrease sensitivity of the formulation to minor variations in raw materials or the manufacturing process. This stimulates the formation of anticoagulant proteins, resulting in dissolution of clot. In accordance with international recommendations, benzathine benzylpenicillin-G is assigned by deep intramuscular injection once every 4 weeks (in some cases, once every 3 weeks). Bancroft A, Wilson S, Cunningham-Burley S et al (2004) Parental drug and alcohol misuse. Quinones and aromatic chemical compounds in particu- late matter induce mitochondrial dysfunction: Implications for ultrafine particle toxic- ity. Clinical signs that seizures are controlled are autonomic stability and the absence of abnormal movement. It affected at least 124 countries in 2011, and the burden is disproportionately felt in the developing world. The maxi- mal dose may be increased to 80 mg, three times daily (20% of patients) Hypertrophic subaortic stenosis: 20 to 40 mg, three or four times daily, oral Dosage adjustment in hepatic impairment: propranolol is almost entirely eliminated by hepatic metabolism and, thus, patients with liver dis- ease may require variable dosage adjustments and more frequent monitoring. Mechanism of action: Iron in ferrous sulfate replaces ferrous iron in formation of hemoglobin which is reduced in anemia. More recently, a survey of amoxicillin in the capital of Papua New Guinea found all samples outside of pharmacopeial specifcations; 14 per- cent had undetectable levels of active ingredient (Nair et al. Declaration of interests: Amanda Feilding declares that she has no conflicts of interests. The achievement of maximum plasma concentrations and removal from plasma of the parent compound are rapid except in patients with compromised renal function. However, more recently, Pollaczek (70) asked college males and naval recruits to simulate feeblemindedness on the comprehension, vocabulary, and similarities subtests of the Wechsler-Bellevue Intelligence Scale (Form I), and found that their mean scores did not differ significantly from the mean scores of the mentally defective control group. For hypoxic patients: • Prednisone, oral, 80 mg daily for 5 days, then taper over 14 days. Storage Store in a tghtly closed container at a temperature not exceeding 30⁰C, away from fre and protected from moisture. Thus, the investigated dental gel is promising for use as a medicine for the treatment of inflammatory diseases of the oral cavity. In some cases they anticipated the later development of large-scale production 1 I wish to thank Eric J. It can be successfully treated with a 12-week course of oral pred- nisolone; if patents do not respond, specialist centre treat- ment is required. Te most common As a minor pathway, it is presumed that the biliary metabolites observed were the glucuro- exocyclic alkene of pulegone is oxidized (with nide conjugates of hydroxylated pulegone and the assumption of an epoxide intermediate) to pulegol (Speijers, 2001). Acidic drugs likely to be affected in- paction, vomiting, diar- clude barbiturates, phenytoin, penicillins, cephalosporins, thyroid rhea, and hemorrhoid ir- hormones, thyroid derivatives, and digoxin. Other thiazide diuretics are considered compatible by American Academy of Pediatrics. Table 2 Financial stability types Financial stability type Solvency Absolute stability High: the firm dont lack loans Normal stability Normal: efficient use of borrowed funds Unstable state Violation: necessary to attract additional sources Crisis Insolvency – bankruptcy stage Effective management strategies development is possible as a result external and internal environment analysis. It thus ofers the prospect of a cure for neurocystcercosis, which has been treatable only by surgery, ant-infammatory cortcosteroids and antconvulsants.

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Metabolic carbon oxidative processes play a signifcant role in reducing bioavail- ability order cheap haldol on-line, where para-hydroxylation of an activated aromatic ring has the largest effect purchase haldol 5 mg with visa, followed by aryl methyl and allylic groups contributing to a lesser extent generic haldol 10 mg online. Standard sieve, 1⁄2-inch sieve (ix) Copper sulfate crystals opening, 12-inch diameter. Strong professional regulation resulted in the absence (until the 1941 establishment of the visa system) of any form of pre-marketing evaluation organized under the authority of the state. Second, I will examine the criteria on which the theoretical examination was based. As discussed in Chapter 1, prodrugs may be used to enhance the absorption of poorly adsorbed drugs by increasing the lipophilicity of the drug molecule. This method of administration prevents the propylene glycol contained in this formulation from causing cardiovascular collapse. The nonsuggesiible subjects, on the other hand, tended to be more threatened by disturbances in body schema, defensive about their intellectual control, and more aware of external factors which reinforce reality. This method is commonly used to calculate creatinine clearance when the "amount of drug" is the amount of creatinine that appears in the urine over 24 hours, t2 - t1 = 24 hours, and Cmidpoint is the serum creatinine determined at the midpoint of the urine collection period. An additional group of 10 female mice received 1000 mg/kg bw per day for 13 weeks and were then maintained without further treatment for a one-month recovery period before termination. This factor is only one component of such evaluations, but it is often important to know how rapidly a drug is made available to the systemic circulation. Such statement shall be set which cannot be separated by good forth on the label with such promi- manufacturing practice) and excess nence and conspicuousness as to render pulp are removed and to which may be it likely to be read and understood by added not more than 10 percent by vol- the ordinary individual under cus- ume of the unfermented juice obtained tomary conditions of purchase. The evaluation of combinatorial libraries using high-throughput screening technologies allows the rapid screening of potential lead compounds with a wider molecular diversity against a broad range of therapeutic targets. The yellow square shows the area used for sample drifting correction: to correct the sample drift during data acqui- sitions. Each of these therapies has multiple effects, aside from enhanced inotropy, which may limit their therapeutic efficacy (e. These tools can also be used to identify appropriate patient populations for clinical investigation and to identify or validate clinically meaningful end points that are accessible in a timeline permissive for drug development. In addition to serving as a site for localized drug delivery for the treat- ment of perifollicular diseases, the follicles can also serve as a long-term reservoir for delivery to surrounding cells in the skin (4). Heparin-induced thrombocytopenia Platelet counts should be monitored in all patients receiving heparin therapy. Vernon and Hoffman (76), after conditions of sensory deprivation lasting twenty-four and forty-eight hours, questioned four subjects about difficulty in focusing, increased saturation of hues, and lack of three-dimensional perception, and reported negative findings for all three phenomena. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. You are hereby required to show cause why action should not be taken to confiscate the goods under Section…………………………………of the Customs Act. Skin: Stevens-Johnson Syndrome, exfoliative dermatitus, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported Haematological System: Anaemia, including haemolytic anaemia, thrombocytopaenia, thrombocytopaenic purpura, eosinophilia, leukopaenia, and agranulocytosis have been reported during therapy with penicillins. Etomidate also decreases the intraocular pressures for 5 minutes after a single dose. The second possibility for the role of etoposide in causing translocations is that it selects for cells that already have translocations. Any qualitative and quantitative changes in an the same formulation and manufacturing procedures, are excipient beyond the ranges noted in level 2 used on the test batch or batches and on the full-scale change. In dence is presented and reviewed critically in the the case of high-output data, there is the possi- context of rigorous criteria for the operation of bility to overinterpret changes in individual end- that mechanism in carcinogenesis (e. If suddenly withdrawn, there may be recurrence of the original anxiety or insomnia. The procedure is then this section, or by any other procedure the same as in paragraph (a)(3)(i) of which produces a finished cheese hav- this section, except that heating is to ing the same physical and chemical 94 °F. Now, if to the resulting supernatant liquid, which is nothing but a saturated solution of barium sul- phate, an additional small quantity of either a soluble barium salt or a soluble sulphate is provided, a slight further precipitation may occur. Like their chemical structures, their biological applications vary widely [154] and this diversity has encouraged their use in the design of new-generation drugs for cancer [155, 156] and for infectious diseases [156, 157]. The resultant mid-log phase cultures was added to each well of the compound containing plates, giving a. Some vaccines are prepared using hens’ eggs and a history of anaphylaxis to egg ingeston is a contrain- dicaton to the use of such vaccines; cauton is required if such vaccines are used in persons with less severe hypersensitvity to egg. If an infusion is stopped before steady state is reached, the concentration could be determined: -Kt Ct = (K0/Cl )(1 - et ) where t = the duration of the infusion. In addition, the purpose of carrying out the drug release studies from the micro/ nanoparticulates is generally to understand the rate and mechanism of drug release rather than as a routine quality control method as used in the case of conventional dosage forms. Dosages are significantly lower for these patients than for patients with schizo- phrenia. Srisurapanont M, Ali R, Marsden J et al (2003) Psychotic symptoms in methamphetamine psychotic in- patients. Ab initio determination of the framework structure of the heavy-metal oxide CsxNb2. The committee sees the model quality assurance system as a useful independent standard to assess procurement agencies. If we let the tip act at the spring’s midpoint, employ appropriate trigonometric identities, and assume uniform geometries and material properties for the length of the spring, the equation may be written explicitly as a function of vertical displacement only:! This technique experimental design is the best method of solving the problem optimization shell color with a minimum number of experiments. In addition, some topical anes- tions may include myo- thetics, such as lidocaine, are combined in other products. These claims have been challenged: other investigators have been impressed by the strength, stability, and resilience of long-established values and social controls, and by rational regard for self-interest, either as limiting the compliance of those subjected to coercive and persuasive influence attempts, or as enabling the subject to resist completely (2, 4, 7, 11, 15, 18, 50, 53, 54, 55, 65, 66, 68). Note: Secondary failure of oral agents occurs in about 5–10% of patients annually. Analysis of Samples product in the immediate pack and then in the marketing At the end of the exposure period, the samples should be pack. It has become apparent that multidisciplinary approaches, employing the combined forces of such disciplines as molecular biology, biotechnology, pathology, pharmacology, immunology, pharmaceutical sciences, engineering, clinical sciences etc. When this drug is administered for the first time an initial infusion of 10% of the total dose over 30 minutes should be given as a ‘test dose’.

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Since no approved human vaccine is available 10 mg haldol, disease control is dependent on drug therapy buy haldol master card, even though the recommended drugs are decades old 10mg haldol fast delivery, induce severe side effects, lead to the emergence of resistances and have limited efficacy due to disease exacerbation mainly associated with compromised immune capability (e. Dittes and Kelley (37) have investigated changes in public and private opinion by group members varying in feelings of acceptance. Emotonal or physical stress, lack of or excess sleep, missed meals, menstruaton, alcohol and specifc foods including cheese and chocolate are ofen identfed as precipitatng factors; oral contraceptves may increase the frequency of atacks. These are made from sheep’s milk or goat’s milk washed in hot whey until the desired or mixtures of these, or one or both of elasticity is obtained. The nature of the Lorentz factor differs from experimental setup to setup, that is, with both the diffraction technique and the crystalline sample type. When the same rats were given 3, 30 or 100 mg phenolphthalein glucuronide by intravenous adminis- tration, no phenolphthalein was detected in the bile (Mehendale, 1990). On the other hand, scaffolds that are active on a variety of receptors may form an attractive starting point in combinatorial library design. On the other hand, ultradeformable liposomes appear to be a unique carrier, in which the remarkable deformability of the vesicles results in the penetration of intact vesicles deep into the skin under osmotic gradi- ent (24). Chromatography As a result, the successful introduction of disposable bioprocessing has largely Moderated by Amy Ritter been enabled by the process intensification that resulted from the increases in expres- sion levels over the past decade. While macrocytosis and megaloblastic anaemia have occurred, these conditions usually respond to folic acid therapy. Test at least 50 (x) Seeds in all styles except whole units, taken at random in containers of uncored style. A stratifed random sample of medicine shops and licensed pharmacies in Laos found 90 percent of artesunate samples failed quality testing (Sengaloundeth et al. In ′ enalaprilat, a P1 alanine residue was adopted to mimic the methyl functional found in ′ captopril. Recommendation 1-1: The World Health Assembly should adopt def- nitions consistent with the following principles. If classical conditioning can be seen as learning through association, then operant conditioning can be seen as learning through reinforcement. Glanz A & Taylor C (1986) Findings of a national survey of the role of general practitioners in the treatment of opiate misuse: extent of contact with opiate misusers. Pharmacodynamics Alpha-adrenergic blockers work in one of two ways: • They interfere with or block the synthesis, storage, release, and reuptake of norepinephrine by neurons. Under a phased-in ap- that could be important in determining that they no longer wish to pursue (3). Chowd- expression in eukaryotic cell line,” Kinetoplastid Biology and hury, “Antibody kinetics in kala-azar in response to treat- Disease, vol. Nervous System: Lightheadedness, dizziness, tingling in arms, numbness, blurred vision, burning sensation Adenosine! Human albumin stored at a temperature not exceeding 25⁰C may be expected to meet the requirements of the monograph for three years from the date on which it was heated at 60⁰C for 10 hours. Cardiovascular System: None known Gastrointestinal System: Nausea & vomiting, diarrhoea, may alter liver function tests Skin Rash, dermatitis, itching, urticaria Haematological System: Anaemia, granulocytopaenia, thrombocytopenia Tobramycin! Microvilli are found on the columnar cells which increase the surface area available for absorption. Such labeling should be in accordance guidance is based on expected shelf lives in that range. These dimensions should make possible a more precise evaluation of different experimental conditions for their relationship to the production of these experiences. Substandard weight variation outside drugs of unknown origin were ampicillin and tetracycline were pharmacopoeial limits substandard. Exponential Equation Diffusional exponent approach has been given by Peppas and colleagues (11,12). Medicines are expensive; patients and governments waste money on ineffective ones. Usually, the aim of this strategy is to improve, somehow, the delivery of lipophilic drugs, which have low inherent solubilities in most of the classical formulation excipients. Government works Printed in the United States of America on acid-free paper 10987654321 International Standard Book Number-10: 1-4200-7804-6 (Hardcover) International Standard Book Number-13: 978-1-4200-7804-6 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Contraindicatons Use in areas of known resistance to either proguanil or pyrimethamine. Other end points, including sleep apnoea, and liver and spleen size, were considered for the primary composite score but were eventually not used. Antibacterial drugs The rise of the resistance Antibacterial drugs, also known as antibiotics (drugs that inhibit movement the growth of bacteria), are used mainly to treat systemic (involv- ing the whole body rather than a localized area) bacterial infec- Indiscriminate use of an- tions. From the comparison of Figures 10(A) and 10(B), one can conclude that lattice-fringe fingerprinting works for both types of crystalline mate- rials, those that do not (Fig. Room Temperature or Refrigerator Brief exposure to temperatures up to 40°C/104°F may be Storage Statement tolerated provided the mean kinetic temperature does not For a drug product demonstrated to be stable both at 25° ± exceed 25°C (77°F). On the basolateral membrane, the presence of amino acid and oligopeptide transporters has been demonstrated. This plete nutrition information as de- number shall be determined by divid- scribed in §101. Secondly, a network of strategic cooperation between bacteriological research, clinicians, pharmaceutical enterprises, and state authorities developed around the serum: the concept of the serum’s „value” bridged the differences between these diverse interest groups because it was broad and fexible enough to be translated from a laboratory to a therapeutic measure and because it assumed an economic and a public health value. The analyzing rotator prism D (Nicol) is fixed in such a manner that it can be rotated easily about the axis of the incident light ray. However, a fourth and undesirable course of action is possible due to the nature of the O-acylisourea, which rearranges to produce the N-acylurea (37) that is a stable inert form of the acid (path D, Scheme 2. Heart failure can also afect metabolism of drugs with rapid hepatc clearance (for example lidocaine, propranolol). Complying "voluntarily" for such cases is less threatening, and may be regarded by them as less shameful, than losing control completely over their actions. The maximum of fill of container for tomato juice, as number of defective sample units per- mitted in the sample in order to con- determined by the general method for sider the lot as meeting the specified fill of container prescribed in §130. Improvement of a direct agglutination test for field studies of visceral leishmaniasis. This patients who have adverse effect isn’t seen when cardioselective drugs are given at respiratory lower doses.

Their mutually reinforcing potential is strengthened where individuals are exposed to ‘trapping factors’ generic haldol 1.5 mg line. As had been the case in the production of sera after 1895 haldol 10mg visa, biological assays played a critical role in measuring the potency of every single batch of the processed material buy haldol without a prescription. Dermatologic: Ischemic skin lesions, circumoral pallor, urticaria Gastrointestinal: Abdominal cramps, flatulence, mesenteric ischemia, nausea, vomiting Genitourinary: Uterine contraction Neuromuscular & skeletal: Tremor Respiratory: Bronchial constriction Metabolic: Hyponatraemia & water retention Vasopressin! The only purpose for which a psychologist would ask a subject to throw acid at another individual would be to contribute to science or new knowledge. For reasons not yet clear to those of us investigating these things “unofficially,” butane (and perhaps other gas/solvents with similar ultra-low-boiling properties) selectively solvate the desirable fraction(s) of cannabis oils, pulling out only a beautiful amber “honey oil” and leaving the undesirable vegetative oils, waxes, chlorophyll, etc. In the case of Na atom E2 designates the highly energetic 4p state and the radiation λ2 obtained therefrom will appear at a relatively shorter wavelength. Characterization of bioconjugates of l-asparaginase and Cu,Zn-superoxide dismutase. Hypoventilation Patients who have received flumazenil for the reversal of benzodiazepine effects (after conscious sedation or general anaesthesia) should be monitored for resedation, respiratory depression, or other residual benzodiazepine effects for an appropriate period (up to 120 minutes) based on the dose and duration of effect of the benzodiazepine employed. Pairs of molecules with similar structure and dissimilar activity were identified first. Not always curative, these drugs can halt the progression of a mycobacterial infection. Pulmonary hypertension after operations for congenital heart disease: analysis of risk fac- tors and management. The health threats posed by such products have led researchers to investigate ways of reliably detecting and identifying these illicit drug compounds; other sophisticated techniques have been shown to detect some analogues, but the high specifcity and sensitivity of mass spec makes it the most popu- lar method (Singh et al. Furnace The furnace must be designed in such a fashion so as to incorporate an appropriate smooth input thereby maintaining either a fixed temperature or a predetermined linear-heating programme (e. Solvent effects on the resonance Raman spectroscopy, electronic absorption spectroscopy and electrochemistry of fullerenes and fullerides. Combining therapeutics with imaging diagnosis, bioimaging captures information that is significant to aspects of biodistribution and delivery efficacy by using a quantified signal. For example, studies have shown that receptor-mediated endocytosis via enterocytes is a major pathway for the intemalization of certain antisense oligonucleotides. Other drug interactions involving iron include: nephrine and standard • Absorption of tetracyclines (demeclocy- emergency equipment cline, doxycycline, minocycline, oxytetracy- readily available. People whose viral load remains detectable following adherence support have probably developed drug resistance and may need to switch regimens. Several research reports have been published on the applications of nanoparticulate drug delivery systems using various drug entities and polymers and different forms of drug delivery systems. Absorption of acetazolamide is dose dependent, and acetazolamide distributes into erythro- cytes and the kidneys. Introduction of innovative forms and methods allows graduate students to experience ourselves as professional; leaving future teachers can effectively evaluate teaching personal inclinations. Lower edge/vector labels precede higher ones; if all labels match, the shorter string precedes the longer. I think the spot on the bend of the arm is so commonly used because it’s so darned easy to get the needle into the vein properly. Note: The addition of metronidazole to amoxicillin/clavulanic acid is unnecessary as amoxicillin/clavulanic acid has adequate anaerobic cover. Blood coagulating amino acids, aminocaproic acid, and tranexamic acid are examined in their own Section 5. Of 60 patients in whom complete remission was achieved, 14 suffered a bone-marrow relapse. There are some studies suggesting that ticlopidine may be slightly more effective in female patients. Higher work of adhesion with the substrate was suspected for small nanowires due to increased capillary effects, or meniscus forces. Soaking in clean water or mild saline soluton is recommended in the acute stages of severe dermatts. Their efficacy has been documented in a number of clinical disorders, including osteoarthritis, rheumatoid arthritis, colds, flu, dysmenorrhea, dental pain and headache. Roberts, who complained hotly of the diffculty he was thrown into due to the study’s untimely publicity: 1 As reprinted in Harvey C. Conversely, if clearance decreases, plasma concentrations will increase because the drug is being removed at a slower rate (Figure 5-6). The object of our study are the names of medicines and dietary supplements, officially registered in pharmaceutical marke of Ukraine, both domestic and foreign production. Multiple approaches have been used to demonstrate changes in the physical stability of lysosomal enzymes as a function of pH, temperature and/or small molecule binding. In mice, the pharmacokinetics of teniposide differs from that of etoposide, a closely related drug, with lower clearance, a larger volume of distribution and a longer terminal elimination half-time. The documents such as master formulae, test specifications, Standard Operating Procedures, batch records (including protocols of analysis and documents relating to the control of printed material and labelling operations) requires close verification. In contrast the silicone-based device described above has been reported to be stable, non-irritating and non-toxic. Currently, two types of electron sources are commonly used in an electron microscope: thermionic and field emissions. These developments have boosted the entry of peptides into clinical phases and therefore their appearance in the market. To define the line, it is necessary to know the steady-state concentrations achieved at a minimum of two different doses. The final diluted solution should be used within 6 hours when stored at room temperature or with 24 hours if refrigerated. As a part of the algorithm associated with the consideration of statistical hypotheses, it is possible only pairwise 2 comparison of models with different numbers of factors. Mechanism of action: Competitively blocks H2 receptors on parietal cells, thereby blocking gastric acid secretion. Anti-Cancer cells were plated at 2 · 10 cells cm into 96-well plates and incubated for 24 h before the addition of drugs. Subjects worked in four- or five-man groups under two different orientations to the task: a normative condition, competing with other groups, and modal conditions, in which they were compared as individuals.